The 23-year-old claimed a tight first set but ran way with the second to earn a 7-5 6-0 triumph over the five-time champion and secure her second Grand Slam title after her French Open success in 2016.
The Venezuela-born ace was given a stern test in the first set and had to save two set points at 5-4, 15-40 down, but then reeled off nine consecutive games as the elder Williams sister wilted under the Centre Court roof.
After receiving the famous gold plate, Muguruza paid tribute to her opponent and apologised for ending her hopes of a fairy tale victory.
“I had the hardest match today against Venus,” she said. “She’s such an incredible player. I grew up watching her play – sorry.
“I feel incredible to be able to play her here. Of course I’m nervous because I always dreamed about winning it, but I was composed.”
And she admitted that words from Venus’s sister had inspired her to go all the way this time around.
“Two years ago I lost in the final against Serena and she told me one day I was going to win,” she added. “Here I am.”
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