Hernandez has been out of action for almost five weeks after suffering a hamstring injury but has been in full training for a week and should be available.
However, manager David Moyes may persist with Michail Antonio up front and with Hernandez on the bench. Moyes will make a late decision on Winston Reid, who has a hamstring problem.
The Hammers are still yet to win under Moyes after losing away at Watford, Everton and Manchester City and earning a respectable point at home to Leicester.
West Ham were unfortunate to come away from City empty-handed and now face the unenviable task of successive matches against Chelsea and Arsenal.
Hernandez’s return will be a boost for West Ham, who have scored just 13 goals in 15 games so far this season.