Gomez, 20, came off the bench in Friday’s goalless draw with Germany but replaced the injured Phil Jones to partner John Stones and Harry Maguire in England’s backline.
Joe Hart, Kyle Walker and Ryan Bertrand come in with Gomez making his full England debut, while Eric Dier retains the captaincy after leading the Three Lions to a goalless draw against world champions Germany on Friday evening.
Ruben Loftus-Cheek starts in midfield alongside Dier after a man-of-the-match display against the Germans, while Rashford plays up front with Leicester’s Jamie Vardy in a quick attack.
Paris Saint-Germain star Neymar skippers Brazil at Wembley, with Manchester City’s Gabriel Jesus and Liverpool playmaker Philippe Coutinho in support.
England XI: Hart, Walker, Bertrand, Gomez, Stones, Maguire, Livermore, Dier, Loftus-Cheek, Vardy, Rashford
More to follow.