The England international has not featured all season because of the issue and reports claim he faces a further lay-off after he had an operation on Monday.
Earlier this month manager Jurgen Klopp admitted Clyne’s recovery had gone backwards.
“He was in a good way and then had a little setback. That’s how back problems are,” he said on November 3. “We showed him to specialists all over the world and it is not a big problem, it just needs time, that is all.”
It is understood Clyne travelled to London with a member of the club’s medical staff for corrective surgery on Monday.
His problem was always viewed as long-term as he was left out of Liverpool’s Champions League squad submitted to UEFA at the start of the season – and a three-month lay-off could mean he misses out again when the window opens for amendments in January.
It puts added pressure youngsters Trent Alexander-Arnold and Joe Gomez, who have been sharing the right-back duties in Clyne’s absence.
Klopp has managed the situation carefully and is reluctant to play one or the other in back-to-back games but with 12 matches between now and the turn of the year he may find he has no choice.
It is the second injury setback for the Reds boss in 24 hours after Sadio Mane returned to Merseyside early after complaining of more hamstring trouble.
Senegal released the pacy forward early after issuing a statement saying he “slightly felt his old injury” after the 2-0 win over South Africa which secured World Cup qualification.